en
Fabian Grein
© Uni Bonn
Dr. Fabian Grein

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Affiliations
  • Institut für Pharmazeutische Mikrobiologie
Research topics
  • microbiology
  • antibiotics
  • gut microbiome
Since 2015 I am an independent Junior Research Group leader in the German Center of Infection Research (DZIF) with a focus on novel antibiotics targets in staphylococci. Within DZIF, we translate results of our fundamental work on the cell biology of microbes, in particular the impact of antibiotics on the cellular organization of cell wall biosynthetic machineries. In this context, I am PI in the DFG-funded TR-SFB 261 “Antibiotic CellMAP”. Based on my broad experience in anaerobic metabolism, I want to shift my future DZIF focus on Microbial Interference mechanisms within the gut microbiome to evaluate innovative non-antibiotic strategies for the control of pathogens.
Selected publications

Grein F, Müller A, Scherer KM, Liu X, Ludwig KC, Klöckner A, Strach M, Sahl H-G, Kubitscheck U, Schneider T (2020) Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids. Nature communications 11:1455.

Kaur P, Rausch M, Malakar B, Watson U, Damle NP, Chawla Y, Srinivasan S, Sharma K, Schneider T, Jhingan GD, Saini D, Mohanty D, Grein F, Nandicoori VK (2019) LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation. Nature communications 10:1231.

Weikum J, Ritzmann N, Jelden N, Klöckner A, Herkersdorf S, Josten M, Sahl H-G, Grein F (2018) Sulfide protects Staphylococcus aureus from aminoglycoside antibiotics but cannot be regarded as a general defense mechanism against antibiotics. Antimicrobial agents and chemotherapy 62:10 e00602–618.

Santos AA, Venceslau SS, Grein F, Leavitt WD, Dahl C, Johnston DT, Pereira IAC (2015) A protein trisulfide couples dissimilatory sulfate reduction to energy conservation. Science 350:1541–1545.

Fabian Grein
© Uni Bonn
Dr. Fabian Grein

Website

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