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Diana Imhof
© Diana Imhof
Prof. Dr. Diana Imhof

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Zugehörigkeiten
  • Pharmazeutisches Institut
Forschungsschwerpunkte
  • pharmaceutical biochemistry
  • bioanalytics
The growing interest in the development and use of biomolecules in biomedical research and practice requires an increase in the diversity of analytical methods and their applications in academia and industry. Part of our research focuses on synthesis, function, and analysis of bioactive peptides with therapeutic relevance. Target molecules are e.g., complex cysteine-rich peptides like FXIIIa inhibitor tridegin and ion channel blocker conotoxins. The bioanalytical methods established for such molecules can be used to investigate the effects of different formulation processes on the structure and activity of proteins and peptides. In addition, we have a strong interest in the impact of ligand/protein-protein interactions such as in case of transient heme binding to proteins or modulation of G-proteins by peptidic tools.
Ausgewählte Publikationen

Elsayed, Y. Y., Kühl, T., Imhof, D. (2024) Edman degradation reveals unequivocal analysis of the disulfide-connectivity in peptides and proteins. Anal. Chem. 96, 10, 4057–4066

Hopp, M.-T., Holze, J., Lauber, F., Holtkamp, L., Rathod, D. C., Miteva, M.A., Prestes, E. B., Geyer, M., Manoury, B., Merle, N. S., Roumenina, L. T., Bozza, M. T., Weindl, G., Imhof, D. (2023) Insights into the molecular basis and mechanism of heme-triggered TLR4 signaling: The role of heme-binding motifs in TLR4 and MD2. Immunology, 13708

Pepanian, A., Binbay, F. A., Roy, S., Nubbemeyer, B., Koley, A., Rhodes, C. A., Ammer, H., Pei, D., Ghosh, P., Imhof, D. (2023) Bicyclic peptide library screening for the identification of Gαi protein modulators. J. Med. Chem., 66(17), 12396–12406

Hopp MT, Alhanafi N, Paul George AA, Hamedani NS, Biswas A, Oldenburg J, Pötzsch B, Imhof D (2021) Molecular insights and functional consequences of the interaction of heme with activated protein C. Antioxid. Redox Signal. 34:32-48.

Diana Imhof
© Diana Imhof
Prof. Dr. Diana Imhof

Webseite

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