Research and Study at the University of Excellence in Bonn

Rector Professor Michael Hoch has now been given the “Order of the Rising Sun, Gold and Silver Rays” of Japan’s Imperial House in recognition of his contribution to academic exchange and Japanese-German understanding. The order, which is one of the highest awarded in Japan for services to civil society, was presented by the country’s Consul-General Setsuko Kawahara on behalf of the Tennō and the Prime Minister of Japan at a ceremony held at her official residence in Düsseldorf.

The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families. However, many of the variants identified in the known genes cannot yet be reliably classified in terms of their causal role in tumor formation. Under the leadership of the University Hospital Bonn (UKB) and the University of Bonn, an international team of researchers has reassessed the medical relevance of a significant number of unclear variants and thus significantly reduced their number. The results of the study have now been published in the renowned journal "American Journal of Human Genetics".

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear. An international research team led by the University Hospital Bonn (UKB) and the University of Bonn has succeeded in answering this question with the help of antibody fragments, so-called nanobodies, which they have identified. They hope that this will lead to potential therapeutic applications. Their results have now been published in the journal "Nature Communications".

Artificial intelligence (AI) methods are here to stay in science and academia. Yet a “one-size-fits-all” approach will not suffice for researchers, as AI programs and models have to be adapted and trained for each project at a minimum, if not self-programmed outright. In a seminar series titled “AI for All”, the University of Bonn thus intends to teach the necessary skill sets to researchers of all disciplines.