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Subtle eye movements optimize vision

Our ability to see starts with the light-sensitive photoreceptor cells in our eyes. A specific region of the retina, termed fovea, is responsible for sharp vision. Here, the color-sensitive cone photoreceptors allow us to detect even the smallest details. The density of these cells varies from person to person. Additionally, when we fixate on an object, our eyes make subtle, continuous movements, which also differ between individuals. Researchers from the University Hospital Bonn (UKB) and the University of Bonn have now investigated how sharp vision is linked to these tiny eye movements and the mosaic of cones. Using high-resolution imaging and micro-psychophysics, they demonstrated that eye movements are finely tuned to provide optimal sampling by the cones. The results of the study have now been published in the journal "eLife".

A “chemical ChatGPT” for new medications

Researchers from the University of Bonn have trained an AI process to predict potential active ingredients with special properties. Therefore, they derived a chemical language model – a kind of ChatGPT for molecules. Following a training phase, the AI was able to exactly reproduce the chemical structures of compounds with known dual-target activity that may be particularly effective medications. The study has now been published in Cell Reports Physical Science.

Faculty of Agriculture at the University of Bonn adopts new name

What has been known up until now as the Faculty of Agriculture at the University of Bonn is being renamed the Faculty of Agricultural, Nutritional, and Engineering Sciences with immediate effect. The faculty is taking this step in order to better reflect the specialist fields that it covers by giving equal weight to the nutritional and engineering sciences alongside the agricultural sciences.

Another step towards decoding smell

We often only realize how important our sense of smell is when it is no longer there: food hardly tastes good, or we no longer react to dangers such as the smell of smoke. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the University of Aachen have investigated the neuronal mechanisms of human odor perception for the first time. Individual nerve cells in the brain recognize odors and react specifically to the smell, the image and the written word of an object, for example a banana. The results of this study close a long-standing knowledge gap between animal and human odor research and have now been published in the renowned journal "Nature".

Talk and Discussion with World-Class Professor Homi K. Bhabha of Harvard

International Days 2024 is all about excellent early-career researchers, international partnerships and dialogue on how to meet global challenges. In addition to the traditional ceremony for the state awards and the DAAD Prize, the Vice Rectorate for International Affairs invites the public to attend a host of info events, talks and workshops. One major highlight will be a keynote lecture by Harvard Professor Homi K. Bhabha, who is an internationally recognized cultural theory scholar.

Innovative catalyst produces methane using electricity

Researchers at the University of Bonn and University of Montreal have developed a new type of catalyst and used it in their study to produce methane out of carbon dioxide and water in a highly efficient way using electricity. Methane can be used, for example, to heat apartments or as a starting material in the chemical industry. It is also the main component of natural gas. If it is produced using green electricity, however, it is largely climate neutral. The insights gained from the model system studied by the researchers can be transferred to large-scale technical catalysts. The system could also be used to produce other important chemical compounds. The study was recently published in the prestigious journal “Nature Chemistry.” 

Central mechanism of inflammation decoded

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear. An international research team led by the University Hospital Bonn (UKB) and the University of Bonn has succeeded in answering this question with the help of antibody fragments, so-called nanobodies, which they have identified. They hope that this will lead to potential therapeutic applications. Their results have now been published in the journal "Nature Communications".

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