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Albert Becker
© Uni Bonn
Prof. Dr. Albert Becker

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Affiliations
  • Institut für Neuropathologie, Universitätsklinikum Bonn
Research topics
  • epilepsy
  • cortical malformations
  • epileptogenesis
Albert Becker is Head of the Section of Translational Epilepsy Research. How transient brain insults and neurodevelopmental lesions turn neuronal networks chronically hyperexcitable is not entirely understood. In this context, his research foci are on the molecular pathogenesis of epilepsy-associated cortical malformations and tumors as well as neuronal plasticity involving acquired channelopathies particularly in epileptogenesis (van Loo et al., Nat Commun 2015; Schoch et al., J Neurosci 2021). His research bridges basic science approaches and clinical translation in the context of epilepsy-associated lesions and tumors (Blümcke et al., New Engl J Med 2017; Cases-Cunillera et al., Neuro Oncol 2021) and inflammatory-related epileptogenesis (Pitsch et al., Ann Neurol 2021).
Selected publications

Cases-Cunillera S, van Loo KMJ, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, Borger V, Dietrich D, Schoch S, Becker AJ. (2021) Heterogeneity and excitability of BRAF V600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss. Neuro Oncol. doi: 10.1093/neuonc/noab268.

Schoch S, Quatraccioni A, Robens BK, Maresch R, van Loo KMJ, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ. (2021) J Neurosci. 41(39):8111-8125.

Pitsch J, van Loo KMJ, Gallus M, Dik A, Kamalizade D, Baumgart AK, Gnatkovsky V, Müller JA, Opitz T, Hicking G, Naik VN, Wachsmuth L, Faber C, Surges R, Kurts C, Schoch S, Melzer N, Becker AJ. (2021) CD8 + T-Lymphocyte-Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy. Ann Neurol 89(4):666-685.

van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat Commun; 6:8688. doi: 10.1038/ncomms9688.

Albert Becker
© Uni Bonn
Prof. Dr. Albert Becker

Website

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