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Evi Kostenis
© Barbara Frommann
Prof. Dr. Evi Kostenis

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Affiliations
  • Institut für Pharmazeutische Biologie
Research topics
  • G-protein-coupled receptors
Research pursued in the Kostenis lab deals with G protein-coupled receptors (GPCRs), the largest family of membrane proteins in the human genome, and their associated signaling circuitries in health and disease. We are particularly interested in the molecular mechanisms GPCRs utilize to engage with their downstream effectors, heterotrimeric G proteins and arrestins, and attempt to elucidate the cellular consequences originating thereform. Essential to this endeavor is access to CRISPR-Cas9-based genome editing as well pharmacological tools to specifically disrupt the function of individual GPCRs and/or their signal transducing effectors. With our cellular manipulations we aim to unravel general principles and basic mechanisms underlying GPCR and G protein function, and how these can be translated to and exploited for development of innovative therapies.
Selected publications

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E (2018) Lack of Beta-Arrestin Signaling in the Absence of Active G Proteins. Nat Commun 9(1):341-

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E (2019) Direct Targeting of Gα q and Gα 11 Oncoproteins in Cancer Cells.Sci Signal 12(573):eaau5948

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E (2015) The Experimental Power of FR900359 to Study Gq-regulated Biological Processes. Nat Commun 14;6:10156

Gutkind JS, Kostenis E (2018) Arrestins as Rheostats of GPCR Signalling. Nat Rev Mol Cell Biol 19(10):615-616.

Evi Kostenis
© Barbara Frommann
Prof. Dr. Evi Kostenis

Website

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