Endothelial cells (ECs) are the smallest functional unit of blood and lymphatic vessels. ECs regulate new vessel growth during health and disease. Blood ECs coordinate nurturing of perivascular tissues, while lymphatic ECs regulate fluid homeostasis and immune cell transport. With the development of single cell sequencing, ECs were recognized to be heterogenous within an organism, building organ-specific vasculatures. My research focusses on the metabolic peculiarities of blood and lymphatic ECs in different vascular beds. In particular, I am interested how ECs use their metabolism to communicate with neighboring organ-specific cells and how they thereby control organ function. It has been shown that ECs can influence organ function by secreting molecules, also known as (lymph)angiocrine signaling. The aim of my group is to characterize the organ-specific EC secretome influencing organ physiology and to delineate how disturbed (lymph)angiocrine signaling leads to disease.