de
Martina Christina Herwig-Carl
© UKB
Prof. Dr. Martina Christina Herwig-Carl

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Zugehörigkeiten
  • Universitäts-Augenklinik Bonn
  • Sektion Ophthalmopathologie
Forschungsschwerpunkte
  • ocular development
  • ophthalmic pathology
  • uveal melanoma
My research focuses on three different areas: (1) uveal melanoma (UM), (2) ophthalmic pathology and (3) ocular development (based on an archive of more than 1000 fetal eyes). I started working on UM in 2010 with a project on the tumor microenvironment followed by the establishment of a modified mouse model of intraocular melanoma in which we have been able to show the influence of macrophages on the tumor pattern, including vasculogenic mimicry. More recently, I have shifted my research focus to epigenetics in UM, including the analysis of histone post-translational modifications in UM tissues and cell lines. As the available cell lines were not representative of the primary tumor, we have recently successfully established tumour spheroids (ALI-PDOs) from fresh UM tissue. In ophthalmic pathology, I focus on clinicopathological correlations to improve the clinical management of ocular diseases and the implementation of AI to aid clinical and histological diagnosis of selected lesions.
Ausgewählte Publikationen

Weber C, Mercieca K, Weller J, Bulirsch LM, Ach T, Holz FG, Loeffler KU, Herwig-Carl MC (2025) SD-OCT-histopathologic correlation in Schnabel’s cavernous optic nerve atrophy. Eye, online ahead of print / doi: 10.1038/s41433-025-03603-w

Herwig-Carl MC, Sharma A, Tischler V, Pelusi N, Loeffler KU, Holz FG, Zeschnigk M, Landreville S, Auw-Haedrich C, Noberini R, Bonaldi T (2024) Mass spectrometry-based profiling of histone posttranslational modifications in uveal melanoma tissue, human melanocytes, and uveal melanoma cell lines – a pilot study. Invest Ophthalmol Vis Sci 65:27.

Bulirsch LM, Loeffler KU, Holz FG, Koinzer S, Nadal J, Müller AM, Herwig-Carl MC (2022) Spatial and temporal expression of nestin, CD44, collagen IX and GFAP in human retinal Müller cells in the developing fetal eye. Exp Eye Res 217:108958

Sharma A, Biswas A, Liu H, Sen S, Paruchuri A, Katsonia P, Lichtarge O, Dakal TC, Maulik U, Gromiha MM, Bandyopadhyay S, Ludwig M, Holz FG, Loeffler KU, Herwig-Carl MC (2019) Mutational landscape of the BAP1 locus reveals an intrinsic control to regulate the miRNA network and the binding of protein complexes in uveal melanoma. Cancers 11(10). pii: E1600.

Martina Christina Herwig-Carl
© UKB
Prof. Dr. Martina Christina Herwig-Carl

Webseite3

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Links

  1. https://www.uni-bonn.de/de/forschung-lehre/forschungsprofil/transdisziplinaere-forschungsbereiche/tra-3-life-1/mitgliederverzeichnis/martina-christina-herwig-carl#research_profile-tab
  2. https://www.uni-bonn.de/de/forschung-lehre/forschungsprofil/transdisziplinaere-forschungsbereiche/tra-3-life-1/mitgliederverzeichnis/martina-christina-herwig-carl#businesscard-tab
  3. https://www.ukbonn.de/experimentelle-ophthalmologie/ag-herwig-carl/