en
Ana Ivonne Vazquez-Armendariz
© Barbara Frommann
Jun-Prof. Dr. Ana Ivonne Vazquez-Armendariz
TRA Steering Committee

Affiliations
  • Argelander Professor TRA Life and Health
  • Life and Medical Sciences Institute (LIMES)
Research topics
  • stem cells
  • lung organoids
  • personalized medicine
My lab primarily focuses on the use of three-dimensional lung organoid systems from murine and human adult somatic stem cells and human induced pluripotent stem cells (iPSCs) to model lung development and disease. Our research goal is to dissect the cellular and molecular crosstalk between lung epithelium and immune cells occurring during lung development, infection, injury and repair; especially, our lab aims at identifying the microenvironmental factors that determine macrophage phenotype during alveolar niche development and replenishment after injury.
Selected publications

1. Vazquez-Armendariz AI, Barroso MM, El Agha E, Herold S (2022) “3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening”. Cells. 11(9):1526. doi: 10.3390/cells11091526.

2. Vazquez-Armendariz AI, Seeger W, Herold S, El Agha E (2021) “Protocol for the generation of murine bronchiolospheres”. STAR Protoc. doi.org/10.1016/j.xpro.2021.100594.

3. Vazquez-Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty R, Vadasz I, Schwemmle M, Kummer, W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S (2020) “Multilineage murine stem cells generate complex organoids to model distal lung development and disease”. EMBO J. e103476. doi: 10.15252/embj.2019103476, 2020.

4. Moiseenko A, Vazquez-Armendariz AI, Kheirollahi V, Chu X, Tata A, Rivetti S, Günther S, Lebrigand K, Herold S, Braun T, Mari B, De Langhe S, Kwapiszewska G, Günther A, Chen C, Seeger W, Tata RP, Zhang JS, Bellusci S, El Agha E (2020) “Identification of a repair-supportive mesenchymal cell (RSMC) population during airway epithelial regeneration”. Cell Reports. 33(12):108549. doi: 10.1016/j.celrep.2020.108549.

Ana Ivonne Vazquez-Armendariz
© Barbara Frommann
Jun-Prof. Dr. Ana Ivonne Vazquez-Armendariz
TRA Steering Committee

-