Bernd Fleischmann
Prof. Dr. Bernd Fleischmann
Affiliations
  • Institut für Physiologie I
Research topics
  • cardiovascular diseases
We explore mechanistic aspects of Cardiovascular Diseases using a combination of in vitro and in vivo models including hiPS cells. We are particularly interested in mending the infarcted heart and are therefore investigating approaches to induce controlled proliferation in adult cardiomyocytes.
Selected publications

Kolossov E+, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren JM, Sasse P, Rubenchik O, Fries JWU, Wenzel D, Geisen C, Xia Y, Lu Z, Duan Y, Kettenhofen R, Jovinge S, Bloch W, Bohlen H, Welz A, Hescheler J, Jacobsen SE, Fleischmann BK+. Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J. Exp. Med. 203:2315-2327 (2006). +Corresponding authors.

Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher U, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Doering B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI+, Fleischmann BK+. Engraftment of connexin43 expressing cells prevents post-infarct arrhythmia. Nature 450(7171):819-824 (2007). +Corresponding authors.

Hesse M., Raulf A, Pilz GA, Haberlandt C, Klein A, Jabs R, Zaehres H, Fügemann C, Zimmermann K, Trebicka J, Welz A, Pfeifer A, Röll W, Kotlikoff MI, Steinhäuser C, Götz M, Schöler HR, Fleischmann BK. Direct visualization of cell division using high resolution imaging of M-phase of the cell cycle. Nature Communications 3:1076 (2012).

Breitbach M+, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SEW, Fleischmann BK+. In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche. Cell Stem Cell. 1;22(2):262-276.e7. doi: 10.1016/j.stem.2018.01.008. (2018). +Corresponding authors.

Bernd Fleischmann
Prof. Dr. Bernd Fleischmann
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