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Carmen Ruiz de Almodóvar
© Barbara Frommann
Prof. Dr. Carmen Ruiz de Almodóvar

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Affiliations
  • Institute for Neurovascular Cell Biology
Research topics
  • neurovascular cell biology
  • CNS
I recently started my new position at the University of Bonn, as the Chair for the new Institute for Neurovascular Cell Biology. The research in this newly funding institute is focused on understanding the properties of the vasculature within the central nervous system (CNS). We aim to address questions as: how is the CNS vascularized?, how do blood vessels grow into the different CNS areas?, how are CNS-specific vascular properties specified and maintained? What are the molecular mechanisms of the cellular crosstalk between vascular cells and the different cells of the CNS? and how are those crosstalk modified in disease conditions? To answer those questions we use in vivo models (mouse), ex vivo organotypic cultures as well as primary cell culture. All this combined with state of the art biochemistry, molecular biology and imaging techniques.
Selected publications

Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D`Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021, 36(7), 109522.

Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C. Oligodendrocyte precursor cell specification is regulated by bi-directional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021, 24, 478–488.

Wang X, Freire Valls A, Shermann G, Shen X, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 2017 Sep 11;42(5):462-478.e7.

Himmels P, Paredes I, Karakatsani A, Luck R, Marti H, Rempel E. Stoeckli E & Ruiz de Almodovar, C. Motoneurons guide blood vessels in the developing spinal cord via a sFlt1 dependent mechanism. Nat Commun. 2017 Mar 6;8:14583.

Carmen Ruiz de Almodóvar
© Barbara Frommann
Prof. Dr. Carmen Ruiz de Almodóvar

Website

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