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Christian Steinhäuser
© Uni Bonn
Prof. Dr. Christian Steinhäuser

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Affiliations
  • Institut für Zelluläre Neurowissenschaften
Research topics
  • neuron-glia interaction
  • epilepsy
Our research is focused on glial cells and their role in information processing in the normal and diseased brain. To unravel mechanisms underlying the hitherto ill-defined forms of neuron-glia interaction and better understand the impact of glial cell heterogeneity, we study different brain regions applying a combination of electrophysiological, molecular and imaging techniques. A main focus of our research is on the analysis of human epilepsy. Here we apply our methods to live hippocampal specimens obtained from neurosurgical treatment of patients suffering from pharmacoresistant temporal lobe epilepsy. In addition, animal models of epilepsy are used. The aim is to better understand the role of glial cells in initiation and progression of epileptogenesis, with the goal of developing new therapeutic approaches.
Selected publications

Philippot C, Griemsmann S, Jabs R, Seifert G, Kettenmann H, Steinhäuser C (2021) Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites. Cell Rep 34:108642.

Deshpande T, Li T, Herde MK, Becker A, Vatter H, Schwarz MK, Henneberger C, Steinhäuser C*, Bedner P (2017) Subcellular reorganization and altered phosphorylation of the astrocyte gap junction protein connexin43 in human and experimental temporal lobe epilepsy. Glia 65:1809-1820. * corresponding author

Bedner B., Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, Deshpande T, Schramm J, Häußler U, Haas C, Henneberger C, Theis M, Steinhäuser C (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138:1208-1222.

Kunze A, Congreso MR, Hartmann C, Wallraff-Beck A, Hüttmann K, Bedner P, Requardt R, Seifert G, Redecker C, Willecke K, Hofmann A, Pfeifer A, Theis M, Steinhäuser C (2009) Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. USA 106:11336-11341.

Christian Steinhäuser
© Uni Bonn
Prof. Dr. Christian Steinhäuser

Website

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