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Christiane Dahl
© Volker Lannert
PD Dr. Christiane Dahl

Website

Affiliations
  • Institut für Mikrobiologie & Biotechnologie
Research topics
  • sulphur metabolism
  • prokaryotes
The main research topic is sulfur metabolism in prokaryotes. Sulfur-metabolizing prokaryotes are of immense importance to the sulfur cycle in both terrestrial and marine habitats. In addition, inorganic sulfur compounds also play an important role in the microbial flora of the human gut. Our work focuses on the biochemical, biophysical and structural characterization of enzymes of bacterial sulfur metabolism not only from environmentally relevant prokaryotes but also from pathogens. Two model organisms, Hyphomicrobium denitrificans and Allochromatium vinosum were made accessible for genetic manipulation and systems biology approaches have been established through national and international collaborations (genomics, transcriptomics, proteomics and metabolomics). Their combination allow an integrated understanding not only of sulfur and energy metabolism in sulfur-oxidizing bacteria.
Selected publications

Cao X, Koch, T., Steffens, L., Finkensieper J, Zigann R, Cronan JE, Dahl C (2018) Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor. eLife 7:e37439. doi: 10.7554/eLife.37439

Ernst C. Kayashta K, Venceslau SS, Pereira IAC, Demmer U, Ermler U, Dahl C (2021) Structural and spectroscopic characterization of a HdrA-like subunit from Hyphomicrobium denitrificans. FEBS . 288:1664-1678. doi: 10.1111/febs.15505

Koch T, Dahl C (2018) A novel bacterial sulfur oxidation pathway provides a new link between the cycles of organic and inorganic sulfur compounds. ISME J 12:2479-2491. doi: 10.1038/s41396-018-0209-7.

Santos A, Venceslau SS, Grein F, Leavitt WD, Dahl C, Johnston DT, Pereira IAC (2015) A protein trisulfide couples dissimilatory sulfate reduction to energy conservation. Science 350:1541-1545. doi: 10.1126/science.aad3558

Christiane Dahl
© Volker Lannert
PD Dr. Christiane Dahl

Website

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