en
Florian I. Schmidt
© Volker Lannert
Prof. Dr. Florian I. Schmidt

Website

Affiliations
  • Institute of Innate Immunity
Research topics
  • viral infection
  • immune signaling
  • nanobodies
The Schmidt lab seeks to uncover molecular mechanisms of the inflammatory response against pathogens. To gain unique insights into protein function, we use custom-made camelid nanobodies to perturb, visualize and ultimately understand immunological signaling cascades and their effectors in the responding cell types. We employ nanobodies and other molecular tools to investigate how virus infection triggers the assembly of inflammasome complexes in various cell types, including primary cells of the immune system, the skin, and intestinal organoids. To delineate common strategies, we compare the responses to a number of DNA and RNA viruses.
Selected publications

Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI (2023) P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J Exp Med. Jan 2;220(1):e20220837.

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI (2021)
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science. Feb 12;371(6530):eabe6230.

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SPJ, Ploegh HL (2016) Phenotypic lentivirus screens to identify functional single domain antibodies. Nat Microbiol Jun 20;1(8):16080.

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL (2016) A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med 213:771-790.

Florian I. Schmidt
© Volker Lannert
Prof. Dr. Florian I. Schmidt

Website

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