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Jacob Nattermann
© Jacob Nattermann
Prof. Dr. Jacob Nattermann

Affiliations
  • Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn
Research topics
  • Natural killer cells / innate lymphoid cells
  • hereditary gastrointestinal tumor syndromes
  • viral infections
As a clinical scientist, I work at the interface between basic immunology and clinical research. In our translational research, we focus on the immunology of natural killer (NK) cells and innate lymphoid cells (ILC). Here, we are particularly interested in the role of these cells in viral infections, hereditary gastrointestinal tumor syndromes, and liver fibrosis. My clinical research aims to identify factors that predict clinical manifestation and optimize surveillance strategies for patients with hereditary gastrointestinal tumor syndromes.
Selected publications

Krämer B, Nalin AP, Ma F, Eickhoff S, Lutz P, Leonardelli S, Goeser F, Finnemann C, Hack G, Raabe J, ToVinh M, Ahmad S, Hoffmeister C, Kaiser KM, Manekeller S, Branchi V, Bald T, Hölzel M, Hüneburg R, Nischalke HD, Semaan A, Langhans B, Kaczmarek DJ, Benner B, Lordo MR, Kowalski J, Gerhardt A, Timm J, Toma M, Mohr R, Türler A, Charpentier A, van Bremen T, Feldmann G, Sattler A, Kotsch K, Abdallah AT, Strassburg CP, Spengler U, Carson WE 3rd, Mundy-Bosse BL, Pellegrini M, O'Sullivan TE, Freud AG, Nattermann J. (2023). Single-cell RNA sequencing identifies a population of human liver-type ILC1s. Cell Rep. 2023 42(1):111937.

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B; Deutsche COVID-19 OMICS Initiative (DeCOI); Aschenbrenner AC, Schultze JL, Nattermann J. (2021) Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 54(11):2650-2669.e14.

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, et al.; Deutsche COVID-19 OMICS Initiative (DeCOI). (2020) Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 182(6):1419-1440.e23.

Jacob Nattermann
© Jacob Nattermann
Prof. Dr. Jacob Nattermann

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