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Jochen Walter
© Uni Bonn
Prof. Dr. Jochen Walter

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Affiliations
  • Klinik für Neurologie, Universitätsklinikum Bonn
Research topics
  • Alzheimer's disease
  • neuronal metabolism
  • amyloid-beta
Alzheimer's disease (AD) is the most common form of dementia and characterized at the neuropathological level by the combined occurrence of intraneuronal aggregates of the microtubule associated protein tau and extracellular β-amyloid plaques. The laboratory of Molecular Cell Biology investigates molecular mechanisms underlying the pathogenesis of Alzheimer’s disease. We apply molecular, cell biological, and biochemical techniques to understand basic processes in neuronal metabolism under physiological and pathophysiological conditions using in vitro and in vivo models as well as human samples. Our research is focused on the functional role of genetic factors, in particular the amyloid β peptide, in the initiation and progression of neurodegeneration. The overall aim of our research is to identify pathways and molecular targets for future therapy and diagnosis.
Selected publications

Venegas Maldonado C*, Kumar S*, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock D, Geyer M, Walter J, Latz E, Heneka MT (2017) Inflammasome-triggered ASC specks cross-seed β-amyloid deposition in Alzheimer's disease. Nature 552:355-361. *equal contribution

Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J (2016) Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathol. 131: 525-537; DOI 10.1007/s00401-016-1546-0,

Glebov K, Löchner M, Jabs R, Lau T, Merkel O, Schloss P, Steinhäuser C, Walter J (2015) Serotonin stimulates secretion of exosomes from microglia cells. GLIA 63: 626-634, doi: 10.1002/glia.22772

Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J (2011) Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J. 30: 2255-2265.

Jochen Walter
© Uni Bonn
Prof. Dr. Jochen Walter

Website

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