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Katrin Paeschke
© J. Saba
Prof. Dr. Katrin Paeschke

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Affiliations
  • Institut für klinische Chemie und klinische Pharmakologie, Universitätsklinikum Bonn
Research topics
  • nucleic acids
  • genome stability
  • DNA damage/repair
My lab focuses on the relevance and function of secondary DNA and RNA structures within cells. We identify and characterise proteins that regulate these structures and contribute to DNA damage/repair, telomere maintenance and mRNA stability. A special focus is to reveal how these structures are sensed in the cell and how changes within these structures affect genome stability and by this impact immunological responses.
Selected publications

Sauer M, Juranek SA, Marks J, De Magis A, Kazemier HG, Hilbig D, Benhalevy D, Wang X, Hafner* M, Paeschke* K., DHX36 prevents the accumulation of translationally inactive mRNAs with G4 structures in untranslated regions Nat Commun. doi: 10.1038/s41467-019-10432-5. (2019)

Wanzek, K., Schwindt, E., Capra, J. A. & Paeschke, K. Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability. Nucleic acids research 45, 7796-7806, doi:10.1093/nar/gkx467 (2017).

Paeschke, K#. et al. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature 497, 458-462, doi:10.1038/nature12149 (2013).

Paeschke, K., Capra, J. A. & Zakian, V. A. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell 145, 678-691, doi:10.1016/j.cell.2011.04.015 (2011).

Katrin Paeschke
© J. Saba
Prof. Dr. Katrin Paeschke

Website

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