en
Marie-Christine Simon
© Marie-Christine Simon
Jun.-Prof. Dr. Marie-Christine Simon
TRA Steering Committee

Website

Affiliations
  • Institut für Ernährungs- und Lebensmittelwissenschaften
Research topics
  • microbiome
  • metabolism
  • gut-brain-axis
The aim of the JRG headed by Marie-Christine Simon is to systematically analyze the impact of commensal microorganisms and their metabolites on the link between nutrition and cognition, with the goal of establishing causative connections between diet, microbiota, metabolism and brain function. To achieve this aim, the JRG pursues a translational approach with mechanistic studies in humans. Finally, the fundamental approach taken by the JRG will be to identify associations between the intestinal microbiome, dietary patterns or food intake, and cognitive function in order to define a healthy microbiota and based on this personalized dietary recommendations and treatments.
Selected publications

Simon M C, Reinbeck A L, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Bäckhed F, Burkart V, Roden M. (2020) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes progression in non-obese diabetic mice J Biol Chem. Jan 24;295(4):969-980.

Simon M C, Möller-Horigome A, Strassburger K, Nowotny B, Knebel B, Müssig K, Herder C, Szendroedi J, Roden MW; German Diabetes Study Group. (2019) Correlates of Insulin-Stimulated Glucose Disposal in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. Jun 1;104(6):2295-2304

Simon M C, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang J H, Stehle P, Pacini G, Hartmann B, Holst J J, MacKenzie C R, Henrich B, Schloot N C, Roden M. (2015) Intake of Lactobacillus reuteri increases incretin and insulin secretion in glucose tolerant human subjects Diabetes Care;38:1–8

Simon M C, Bilan S, Nowotny B, Dickhaus T, Burkart V, Schloot N C; (2013) Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes Clinical and Experimental Immunology Jun;172(3):383-93

Marie-Christine Simon
© Marie-Christine Simon
Jun.-Prof. Dr. Marie-Christine Simon
TRA Steering Committee

Website

-