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Markus Nöthen
© Uni Bonn
Prof. Dr. Markus Nöthen
TRA Steering Committee

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Affiliations
  • Institut für Humangenetik, Universitätsklinikum Bonn
Research topics
  • genetics
  • multifactorial diseases
The focus of my work is to investigate genetic mechanisms of common multifactorial diseases as well as disease-associated quantitative measures (e.g. eQTLs). In addition to formal genetic studies the expertise is to use large-scale molecular genetic studies to identify disease-associated genes at the molecular level. This has led to the identification of genes involved in a variety of disorders including bipolar affective disorder, schizophrenia, dyslexia, common forms of baldness, and cleft lip /cleft palate. I am continuously interested in understanding the complex genetic architecture of these diseases, and how this may involve gene-gene and gene-environment interactions.
Selected publications

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, (…), Nöthen MM (2017) Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness, Nat Commun 8:14694.

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci, Nature 511:421-427.

Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, (...), Priebe L, Czerski PM, (...), Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M*, Nöthen MM*, Cichon S* (2014) Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Commun 5:3339.

Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A, Becker J, Herberz R, AlChawa T, Nasser E, Böhmer AC, Mattheisen M, Alblas MA, Barth S, Kluck N, (…), Hoffmann P, Lange C, Cichon S, Propping P, Knapp M, Nöthen MM (2012) Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet 44:968-971.

Markus Nöthen
© Uni Bonn
Prof. Dr. Markus Nöthen
TRA Steering Committee

Website

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