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Martin Fuhrmann
© Prof. Dr. Martin Fuhrmann
Prof. Dr. Martin Fuhrmann

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Affiliations
  • Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Research topics
  • Alzheimer's disease
  • microglia
The research focus of my group are cellular mechanisms contributing to neurodegenerative diseases, especially Alzheimer's disease (AD). I am interested how neuronal networks from the synaptic to neuronal level are disturbed during learning and memory processes under AD-like conditions. Furthermore, I am investigating how microglia influence neuronal networks, neurons and synapses in the context of learning and memory. To address these questions, we apply multiphoton (2P, 3P) in vivo imaging, combine it with opto- and chemogenetics, as well as electrophysiological and behavioral measurements.
Selected publications

Poll S, Mittag M, Musacchio F, Justus LC, Ambrad Giovannetti E, Steffen J, Wagner J, Dammer L, Schoch S, Schmidt B, Jackson WS, Ehninger D, Fuhrmann M. (2020) Memory trace interference impairs recall in a mouse model of AD. Nat. Neurosci. in press.

Pfeiffer T, Poll S, Bancelin S, Angibaud J, Inavalli VK, Keppler K, Mittag M, Fuhrmann M*, Nägerl UV*. (2018) Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo. eLife, 7:e34700. *equal contribution,

Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M. (2016) Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron, 92(1):114-125

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. (2015) Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol., (5):619-31.

Martin Fuhrmann
© Prof. Dr. Martin Fuhrmann
Prof. Dr. Martin Fuhrmann

Website

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