Oliver Brüstle
Prof. Dr. Oliver Brüstle
TRA Steering Committee
Affiliations
  • Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn
Research topics
  • stem cells
  • cell reprogramming
Our work focuses on the use of human pluripotent stem cells for neuroregeneration and CNS disease modeling. To that end we employ classic iPSC reprogramming and neural differentiation, transcription factor-based forward programming and direct somatic cell fate conversion. Neuronal and glial subtypes are used to devise new transplant strategies and to study mechanisms underlying neurodegenerative and neuropsychiatric diseases in 2D and 3D cell culture models.
Selected publications

Wen, J., Zellner, A., Braun, N.C., Bajaj, T., Gassen, N.C., Peitz, M., Brüstle, O. (2023) Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry. 13:143. doi: 10.1038/s41398-023-02432-3.

Mathews, M., Wißfeld, J., Flitsch, L.J., Shahraz, A., Semkova, V., Breitkreuz, Y., Neumann, H., Brüstle, O. (2023) Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable iPSC-derived human microglia. Stem Cell Rev Rep. 19:455-474. doi: 10.1007/s12015-022-10433-w.

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, H., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M., Brüstle, O. (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation Nat Commun. 29:4047. doi: 10.1038/s41467-018-06398-5.

Doerr, J., Schwarz, M.K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., Schwarz, I., Diedenhofen, M., Braun, N.C., Koch, P., Peterson, D.A., Kubitscheck, U., Hoehn, M., Brüstle, O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nat Commun. 8:14162. doi: 10.1038/ncomms14162.

Oliver Brüstle
Prof. Dr. Oliver Brüstle
TRA Steering Committee
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