en
Stephanie Jung
© UKB
Jun.-Prof. Dr. Stephanie Jung

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Affiliations
  • Institute of Cardiovascular Immunology
Research topics
  • virus-host interaction
  • viral infection
  • extracellular vesicles
Early virus-host interactions are an interplay of viral exploitation of cellular proteins, functions, and innate defence mechanisms. Our research aims at answering the following questions: Which mechanisms and specific patterns lead to the recognition of a viral infection? What does a virus do to evade this recognition? Which cellular structures resemble viruses? In which cells are viral infections actually recognized – the non-infected, or the infected ones? We are taking a closer look on the constant struggle between viruses and the immune system, with special emphasis on extracellular vesicles (EVs). In recent years, this new and highly interdisciplinary field has led to many surprising discoveries and shows a high potential for further scientific developments.
Selected publications

Steinberg, J., Wadenpohl, T., Jung, S. (2021). The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells. Viruses. 13(8), 1564

Jung, S., Jacobs, K.F.K., Shein, M.,. Schütz, A.K., Mohr, F., Stadler, H., Stadler, D., Lucko, A.M., Altstetter, S.M., Wilsch, F., Deng, Li., Protzer, U. (2020), Efficient and reproducible depletion of Hepatitis B virus from plasma derived extracellular vesicles, Journal of extracellular vesicles 10(2):e12040

Jung, S., von Thülen, T., Yang, I., Laukemper, V., Rupf, B., Janga, H., Panagiotidis, G., Schön, A., Nicolai, M., Schulte, L., Obermann, H-L., Weber, F., Kaufmann, A., Bauer, S. (2020) A Ribosmal RNA fragment with 2’,3’-cyclic phosphate and GTP- binding activity acts as RIG-I ligand, Nucleic Acid Research, Vol. 48, No. 18 10397–10412

Jung, S., Altstetter, S.M., Wilsch, F., Shein, M., Schütz, A.K., Protzer, U. (2020), Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages, Matters https://push-zb.helmholtz-muenchen.de/deliver.php?id=26671

Stephanie Jung
© UKB
Jun.-Prof. Dr. Stephanie Jung

Website

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