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Susanne Schoch McGovern
© Barbara Frommann
Prof. Dr. Susanne Schoch McGovern

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Affiliations
  • Institut für Neuropathologie, Universitätsklinikum Bonn
Research topics
  • plasticity
  • synapses
  • synaptopathies
Our group has an overarching research interest in understanding the molecular mechanisms of synaptic computation. The process of vesicular exocytosis of neurotransmitters is highly adaptable to neuronal activity, and alterations in synaptic properties have been proposed to be a fundamental mechanism for modifying the functional properties of neuronal networks, and thereby contributing to phenomena such as learning and memory. Her research focuses on the following questions: (1) what are the molecular mechanisms that regulate synaptic function and plasticity, (2) how do these mechanisms differ between functionally distinct types of synapses, (3) how does synaptic dysfunction contribute to the development of cognitive disorders and hyperexcitability. To address these questions the Schoch lab employs molecular, biochemical, and morphological techniques, FLIM/FRET, dSTORM, time-lapse, 2-photon, confocal and widefield imaging, viral transduction, and experimental animal models.
Selected publications

Müller JA, Betzin J, Santos-Tejedor J, Mayer A, Oprişoreanu A-M, Engholm-Keller K, Paulußen I, Gulakova P, McGovern TD, Gschossman LJ, Schönhense E, Wark JR, Lamprecht A, Becker AJ, Waardenberg AJ, Graham ME, Dietrich D, Schoch S (2022) A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Cell Reports 39:110696.

Schoch S, Quatraccioni A, Robens BK, Maresch R, Loo KMJ van, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ (2021) Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. J Neurosci Official J Soc Neurosci 41:8111-8125.

Loo KMJ van, Rummel CK, Pitsch J, Müller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S (2019) Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. J Neurosci 39:3175-3187.

Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S (2013) RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization. J Neurosci 33:824-839.

Susanne Schoch McGovern
© Barbara Frommann
Prof. Dr. Susanne Schoch McGovern

Website

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