en
Waldemar Kolanus
© Uni Bonn
Prof. Dr. Waldemar Kolanus
TRA Steering Committee

Website

Affiliations
  • Life & Medical Sciences Institute (LIMES)
  • Sprecher Exzellenzcluster ImmunoSensation2
Research topics
  • immune cells
  • cell activation
  • differentiation
  • migration
Our group works on mechanisms of intracellular signal transduction in fundamental biological processes, including cellular activation, differentiation, and migration. An emerging concept is the high systemic interdependence of cellular communication pathways. Our main interest is the elucidation of circuits, which link immune control mechanisms to tissue renewal/maintenance and metabolic stress regulation. We are specifically interested in the elucidation of cytoplasmic enzymes and adapter proteins, which control motility and activation of mammalian immune cells. Furthermore, we have embarked on the elucidation of novel nucleic-acid/protein interactions, which act at the core of controlling “stemness”/differentiation checkpoints in stem cells, in embryonic tissue, and in tumor cells.
Selected publications

Jux B, Gosejacob D, Tolksdorf F, Mandel C, Rieck M, Namislo A, Pfeifer A, Kolanus W (2019) Cytohesin-3 is required for full insulin receptor signaling and controls body weight via lipid excretion. Sci Rep 9:3442.

Torres-Fernández LA, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, Kolanus W (2019) The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21. Nucleic Acids Res 47:11861–11879.

Bald T et al. (2014) Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507:109–113.

Ulbricht A, Eppler FJ, Tapia VE, van der Ven PFM, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J (2013) Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol 23:430–435.

Waldemar Kolanus
© Uni Bonn
Prof. Dr. Waldemar Kolanus
TRA Steering Committee

Website

-