Prof. Katrin Paeschke
Affiliations
- Institute of Clinical Chemistry and Clinical Pharmacology
- Medical Faculty
Research topics
- Nucleic acid structures formation and function in cells
- Protein - DNA or RNA interaction
- Genome stability regulation
- Nucleic acid structure mediated immune changes
The Paeschke lab is interested in the dynamic regulation of secondary DNA and RNA structures and how they are targeted in cells.
Selected publications
De Magis, A., Limmer, M., Mudiyam, V. et al. UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence. Nat Commun 14, 6705 (2023). https://doi.org/10.1038/s41467-023-42494-x
De Magis, A., Götz, S., Hajikazemi, M. et al. Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair. Nat Commun 11, 3907 (2020). https://doi.org/10.1038/s41467-020-17701-8
Sauer, M., Juranek, S.A., Marks, J. et al. DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions. Nat Commun 10, 2421 (2019). https://doi.org/10.1038/s41467-019-10432-5
Prof. Katrin Paeschke