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Margret Bülow
© T. Bülow
PD Dr. Margret Bülow

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Affiliations
  • Life and Medical Sciences Institute (LIMES)
  • Faculty of Mathematics and Natural Sciences
Research topics
  • Membrane contact sites in neurons
  • In vivo modelling and imaging in Drosophila melanogaster brains
  • Organelle dynamics
  • Super-resolution microscopy
I am interested in organelle communication and contact site dynamics. My lab studies these dynamics in vivo in neurons of the fruitfly Drosophila melanogaster. We found that peroxisomes control mitochondrial activity (Bülow et al., 2018, Sellin et al., 2018). Moreover, we found that phospholipid exchange between endoplasmic reticulum and mitochondria controls the formation of hydrogen peroxide, which is required for the activity of dopaminergic neurons and controls systemic locomotor ability.
Selected publications

Paradis, M., Kucharowski, N., Edwards Faret, G., Maya Palacios, S. J., Meyer, C., Stümpges, B., … Bülow, M. H. (2022). The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Science Advances, 8(29). https://doi.org/10.1126/sciadv.abo0155

Sellin, J., Wingen, C., Gosejacob, D., Senyilmaz, D., Hänschke, L., Büttner, S., … Bülow, M. H. (2018). Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PLoS Biology, 16(6). https://doi.org/10.1371/journal.pbio.2004893

Bülow, M.H., Wingen, C., Senyilmaz, D., Gosejacob, D., Sociale, M., Bauer, R., … Sellin, J. (2018). Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Molecular Biology of the Cell, 29(4). https://doi.org/10.1091/mbc.E17-08-0535

Margret Bülow
© T. Bülow
PD Dr. Margret Bülow

Website

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